abstract：:We have used DNA and protein polymorphisms for the third complement component (C3) to assess the potential of DNA markers in the diagnosis and study of familial hypercholesterolaemia (FH), and to confirm the reported linkage between FH and C3. The inheritance of FH and the C3 gene has been studied in 10 families by co...

journal_title：Atherosclerosis

authors： Humphries SE,Donald JA,McFadden JJ,Shull S,Williamson R,Jowett NI,Galton DJ,Julsrud JO,Berg K,Heiberg A

更新日期：1984-09-01 00:00:00

abstract：:Arteriolar wall thickness was measured in cigarette smokers by means of eyepiece micrometry, paper planimetry and computerized planimetry. Myocardial and renal arterioles in such smokers showed significant thickening of their walls. This thickening was mainly attributable to an increase in collagen and smooth muscle. ...

journal_title：Atherosclerosis

authors： Oberai B,Adams CW,High OB

更新日期：1984-08-01 00:00:00

abstract：:We studied the aortic histology of 28 Macaca nigra males and females, from 6 to more than 20 years old, normal and manifesting various degrees of spontaneous diabetes. Correlations of several metabolic and hormonal indicators of diabetes severity with gross and microscopic findings in the aortas demonstrated direct as...

journal_title：Atherosclerosis

authors： Howard CF Jr,Vesselinovitch D,Wissler RW

更新日期：1984-07-01 00:00:00

abstract：:In chronic schizophrenic patients treated with phenothiazines (Chlorpromazine, Levomepromazine, Perphenazine) for long periods (average = 8 years), high density lipoprotein cholesterol (HDL-C) levels were significantly lower (P less than 0.001) compared with normal controls. The HDL subfractions showed that HDL3-C was...

journal_title：Atherosclerosis

authors： Sasaki J,Kumagae G,Sata T,Kuramitsu M,Arakawa K

更新日期：1984-05-01 00:00:00

abstract：:A sub-strain of male and female spontaneously hypertensive rats (SHR) capable of having massively obese or non-obese offspring were bred repeatedly or were maintained as virgin controls. When the male and female breeders had sired or given birth to 5 litters of young, they were autopsied along with their 10-month-old ...

journal_title：Atherosclerosis

authors： Wexler BC

更新日期：1984-05-01 00:00:00

abstract：:The levels of apolipoproteins B, E and A-1 and the molecular species of triacylglycerols, phospholipids and cholesteryl esters were individually quantitated by electroimmunoassay and gas chromatographic total lipid profiling in 50 fresh samples of umbilical cord sera obtained from full term, normal delivery, healthy h...

journal_title：Atherosclerosis

authors： Dolphin PJ,Breckenridge WC,Dolphin MA,Tan MH

更新日期：1984-04-01 00:00:00

abstract：:A combined gross and histologic study carried out on 270 selected male subjects with the common type of distribution of the coronary arteries revealed a natural resistance to intimal thickening and plaque development exhibited by the left main coronary artery and by the first centimeter of the right coronary artery. T...

journal_title：Atherosclerosis

authors： Velican C,Velican D

更新日期：1984-02-01 00:00:00

abstract：:Collagenous components were extracted from bovine aorta by pepsin digestion. Differential salt precipitations separated the interstitial from the basement membrane (BM) collagens, and the latter were subsequently separated into three distinct types. Ion exchange chromatography, SDS-slab gel electrophoresis, cyanogen b...

journal_title：Atherosclerosis

authors： Leushner JR,Haust MD

更新日期：1984-01-01 00:00:00

abstract：:The effect of a fish lipid concentrate rich in eicosapentaenoic acid was studied in 107 subjects for periods up to 2 years. Ninety-two had heart disease or hyper-lipidaemia and 15 had no history of heart disease. Serum triglyceride levels were rapidly reduced, cholesterol fell more slowly but high density lipoprotein ...

journal_title：Atherosclerosis

authors： Saynor R,Verel D,Gillott T

更新日期：1984-01-01 00:00:00

abstract：:Since VLDL and LDL are involved in atherogenesis, their response to dietary modification was studied in 15 normal male prisoners. A 3-month reference diet (P/S ratio 0.3, daily cholesterol intake 370 mg) was compared with a modified fat diet (P/S 1.0, 250 mg) given for further 3 months. The decrement in serum choleste...

journal_title：Atherosclerosis

authors： Weisweiler P,Drosner M,Janetschek P,Schwandt P

更新日期：1983-12-01 00:00:00

abstract：:The rates of cholesterol synthesis from acetate were studied in freshly isolated peripheral blood lymphocytes in 41 age- and sex-matched subjects with essentially normal serum lipid profiles. Insulin binding to erythrocytes obtained from the same blood samples was also studied simultaneously. From the data on lymphocy...

journal_title：Atherosclerosis

authors： Sanghvi A,Virji MA,Warty V,Dimasi MJ

更新日期：1983-12-01 00:00:00

abstract：:An attempt was made to explore the reasons why men develop coronary heart disease (CHD) despite being at low risk on the basis of established risk factors. A case control study was designed to take place after the end of a longitudinal study in which both low- and high-risk men who had developed CHD over the course of...

journal_title：Atherosclerosis

authors： Heller RF,Miller NE,Wheeler MJ,Kind PR

更新日期：1983-11-01 00:00:00

abstract：:Low density lipoproteins (LDL) isolated by ultracentrifugation induce cytotoxic changes in cultured human endothelial cells (EC) and fibroblasts if the ratio between LDL cholesterol and the final protein concentration of the culture medium exceeds 0.10-0.12 mmol/g protein. In order to investigate if reactive oxygen sp...

journal_title：Atherosclerosis

authors： Evensen SA,Galdal KS,Nilsen E

更新日期：1983-10-01 00:00:00

abstract：:This experiment involved examination of the effects of gender and social status ('competitive dominance') on the coronary artery atherosclerosis of cynomolgus monkeys. Thirty-two adult Macaca fascicularis (16 males, 16 females) were fed a diet containing a moderate amount of cholesterol (0.56 mg/cal) for 16 months. Th...

journal_title：Atherosclerosis

authors： Hamm TE Jr,Kaplan JR,Clarkson TB,Bullock BC

更新日期：1983-09-01 00:00:00

abstract：:A marked reduction of serum cholesterol was obtained by treatment with probucol in heterozygous as well as in homozygous cases of familial hypercholesterolemia. A strict dietary regimen (low-fat, low-calories) intensified the hypocholesterolemic effect of the drug. The drug was also useful in diminishing the rebound o...

journal_title：Atherosclerosis

authors： Yamamoto A,Matsuzawa Y,Kishino B,Hayashi R,Hirobe K,Kikkawa T

更新日期：1983-08-01 00:00:00

abstract：:Serum HDL-cholesterol (HDLc) levels were studied on 2399 healthy urban inhabitants, from newborn to 78 years of age, in Shanghai. The results were as follows. (1) Frequency distribution of serum HDLc levels in most groups was approximately normal after age 20. (2) The serum HDLc levels and HDLc/total cholesterol ratio...

journal_title：Atherosclerosis

authors： Chen H,Zhuang H,Han Q

更新日期：1983-07-01 00:00:00

abstract：:We studied the effect of probucol on lipoprotein composition and VLDL apo B turnover. In 7 hypercholesterolemic subjects, probucol therapy lowered mean total cholesterol, HDL cholesterol and HDL triglycerides, raised LDL triglycerides and did not change LDL cholesterol. LDL cholesterol:LDL triglycerides mass ratios fe...

journal_title：Atherosclerosis

authors： Lock DR,Kuisk I,Gonen B,Patsch W,Schonfeld G

更新日期：1983-06-01 00:00:00

abstract：:The effects of chronic renal failure (CRF) and corticosteroid treatment on the aortic uptake of labelled free and esterified cholesterol (FC and EC) were investigated in normocholesterolemic rabbits. Methylprednisolone, 0.4 mg/day, or placebo was administered for 14 weeks to rabbits with normal renal function and with...

journal_title：Atherosclerosis

authors： Tvedegaard E,Szpirt W,Nielsen M

更新日期：1983-05-01 00:00:00

abstract：:The detailed distribution of atherosclerotic lesions in the branching region of the left main coronary artery in man was studied. Tissue cubes of the hearts, containing the left coronary arteries, were removed, and 1.5-mm-thick parallel and consecutive slices were cut perpendicular to the main coronary artery. Histolo...

journal_title：Atherosclerosis

authors： Grøttum P,Svindland A,Walløe L

更新日期：1983-04-01 00:00:00

abstract：:AMO 1618 (2-isopropyl-4-dimethylamino-5-methylphenyl-1-piperidine carboxylate methyl chloride) was added to corn-soy based diets and fed to 9-week-old female chickens for 3 weeks to measure the inhibition of hepatic beta-hydroxy-beta-methylglutaryl coenzyme A (HMG-CoA) reductase and cholesterol 7 alpha-hydroxylase. Do...

journal_title：Atherosclerosis

authors： Qureshi AA,Abuirmeileh N,Burger WC,Din ZZ,Elson CE

更新日期：1983-02-01 00:00:00

abstract：:Experiments were undertaken on excised rabbit common carotid arteries to assess whether the distribution volume for radioactively labelled albumin is influenced by smooth muscle tone or externally applied stress. In arteries at relaxed length and zero transmural pressure, the distribution volume in the media was reduc...

journal_title：Atherosclerosis

authors： Caro CG,Lever MJ

更新日期：1983-01-01 00:00:00

abstract：:The effect of guar (15.6 g/day), a dietary fibre, and simultaneous administration of bezafibrate (600 mg/day) during dietetic treatment on the plasma lipoproteins and apolipoproteins was investigated in 12 patients with familial hypercholesterolemia (corresponding to the HLP type IIa pattern). Either bezafibrate alone...

journal_title：Atherosclerosis

authors： Wirth A,Middelhoff G,Braeuning C,Schlierf G

更新日期：1982-12-01 00:00:00

abstract：:The acidic glycosaminoglycans (AGAG) of the human coronary arterial tree (the main left and right branches and their distal portions) were analyzed by enzymatic methods employing chondroitinases, hyaluronidase and heparitinase. The AGAG content of human coronary arteries was highest in the left branch, intermediate in...

journal_title：Atherosclerosis

authors： Murata K,Yokoyama Y

更新日期：1982-10-01 00:00:00

abstract：:The hypolipidemic efficacy of ciprofibrate was evaluated in patients with type II hypercholesterolemia. Patients were randomized to placebo or ciprofibrate (50 mg or 100 mg/day) and, after a 6-week baseline period, received medication for a period of 12 weeks. Blood samples were analyzed every 2 weeks. Twenty patients...

journal_title：Atherosclerosis

authors： Illingworth DR,Olsen GD,Cook SF,Sexton GJ,Wendel HA,Connor WE

更新日期：1982-08-01 00:00:00

abstract：:Serum lipids, lipoproteins and Achilles tendon thickness in 52 patients with heterozygous familial hypercholesterolemia (FH) were investigated in order to clarify what are the important factors for the development of coronary artery disease (CAD) in heterozygous FH patients. There were no significant differences in th...

journal_title：Atherosclerosis

authors： Hirobe K,Matsuzawa Y,Ishikawa K,Tarui S,Yamamoto A,Nambu S,Fujimoto K

更新日期：1982-08-01 00:00:00

abstract：:Rabbits were fed a semipurified diet containing soy protein for 4 weeks and subsequently transferred to a semipurified diet containing soy protein plus cholesterol (2 g/kg), or a semipurified diet containing casein as protein source. One group of rabbits was fed the soy protein diet throughout the entire experimental ...

journal_title：Atherosclerosis

authors： Scholz KE,Beynen AC,West CE

更新日期：1982-07-01 00:00:00

abstract：:Serum high density lipoprotein cholesterol (HDL-C), total cholesterol (TC) and triglycerides (TG) were determined, and values of low density lipoprotein cholesterol (LDL-C), HDL-C/TC (%), and the LDL-C/HDL-C (ratio) were calculated in 1101 healthy Chinese men and women, 77 patients with coronary heart disease (CHD), 7...

journal_title：Atherosclerosis

authors： Cai HJ,Li ZX,Yang SM

更新日期：1982-06-01 00:00:00

abstract：:Following injections of Evans blue (1-200 mg/kg) into rabbits, polyacrylamide gel disc electrophoresis showed that Evans blue binds to two protein fractions. The greater part was bound to albumin and the remainder to a plasma protein in the postalbumin fraction. Unbound Evans blue was present in each plasma sample ana...

journal_title：Atherosclerosis

authors： Lindner V,Heinle H

更新日期：1982-06-01 00:00:00

abstract：:The aim of this study was to determine whether an abnormality in low density lipoprotein (LDL) metabolism could be demonstrated in fibroblasts cultured from normolipidaemic subjects with atherosclerosis. Seventeen male subjects aged 30-55 years with normal plasma lipid concentrations were divided into 2 groups on the ...

journal_title：Atherosclerosis

authors： Behrman RG,Wynn V

更新日期：1982-04-01 00:00:00

abstract：:Rabbit aortic smooth muscle cells (SMCs) were successfully subcultured in 10% hyperlipidemic rabbit serum (HLS) for at least 9 passages. SMCs grown in HLS grew into higher cell densities than SMCs cultured in normolipidemic rabbit serum (NLS) for at least 4-5 passages in NLS and HLS, respectively. However, cells cultu...

journal_title：Atherosclerosis

authors： Pietilä K

更新日期：1982-03-01 00:00:00

abstract：:Two preparations active in reducing hepatic cholesterolgenesis in vitro were demonstrated in human milk. These appear to affect the cholesterol synthetic pathway at different loci. One inhibits the synthesis before the formation of mevalonic acid and has been isolated and subsequently identified as uric acid. The othe...

journal_title：Atherosclerosis

authors： Ward PC,McCarthy RD,Kilara A

更新日期：1982-02-01 00:00:00

abstract：:Serum triglycerides, cholesterol, HDL-C and LDL-C levels as well as the LDL/HDL cholesterol ratio were determined in 11 patients suffering from hyperthyroidism and 7 patients suffering from hypothyroidism, and compared with those of 19 sex-and age-matched controls. In hypothyroidism a net increase of all lipid values ...

journal_title：Atherosclerosis

authors： Raziel A,Rosenzweig B,Botvinic V,Beigel I,Landau B,Blum I

更新日期：1982-02-01 00:00:00

abstract：:The effect of colestipol on plasma lipids and lipoproteins was studied in children, adolescents and young adults with familial hypercholesterolemia. O.125 g or 0.25 g/kg body weight were given in randomized sequence for period of 4 weeks. Total cholesterol was lowered by 13 and 18% with the smaller and larger dose , r...

journal_title：Atherosclerosis

authors： Schlierf G,Mrozik K,Heuck CC,Middelhoff G,Oster P,Riesen W,Schellenberg B

更新日期：1982-01-01 00:00:00

abstract：:Mevinolin (MK-803) is a potent inhibitor of HMG-CoA reductase. After a placebo run-in period, mevinolin 5,15 or 50 mg, or placebo was given twice daily for 7-11 days under double -blind conditions ot 4 groups of 6 normocholesterolemic male volunteers. After 7 days, mean serum cholesterol fell 14%, 25% and 24% on 5, 15...

journal_title：Atherosclerosis

authors： Tobert JA,Hitzenberger G,Kukovetz WR,Holmes IB,Jones KH

更新日期：1982-01-01 00:00:00

abstract：:The postheparin plasma lipoprotein lipase (LPL) activity and plasma HDL and LDL cholesterol concentrations, decreases significantly during probucol treatment of the rat. The reduction of the LPL activity obviously took place in adipose tissue. The activity of hepatic lipase and the in vitro synthesis of cholesterol in...

journal_title：Atherosclerosis

authors： Strandberg T,Kuusi T,Tilvis R,Miettinen TA

更新日期：1981-11-01 00:00:00

abstract：:Gross dissection of the coronary arteries of 566 subjects aged 0--45 years from an unselected population sample of Bucharest revealed the presence of a similar anatomical branching pattern in 58% of cases. Starting from this common type of distribution of coronary arteries, some minor deviations were detected coexisti...

journal_title：Atherosclerosis

authors： Velican D,Velican C

更新日期：1981-11-01 00:00:00

abstract：:Rabbits were continuously exposed to 200 ppm carbon monoxide. Using the same criteria as applied by earlier investigators for morphological myocardial damage, no histotoxic effect on myocardial morphology could be demonstrated when electron-microscopic investigations were performed blindly. Similarly, exposure to 0.5 ...

journal_title：Atherosclerosis

authors： Hugod C

更新日期：1981-10-01 00:00:00

abstract：:The local anesthetic lidocaine was studied for its effects on lipid metabolism in aortas from normal rats, rabbits, and cholesterol-fed (atherosclerotic) rabbits in vitro. Incubation of aortas in the presence of 3--5 mM lidocaine resulted in a statistically significant reduction in the incorporation of [14C]oleate int...

journal_title：Atherosclerosis

authors： Bell FP,Hubert EV

更新日期：1981-07-01 00:00:00

abstract：:The effect of triiodothyronine (T3) on prostacyclin production in rat aortic smooth muscle cells was investigated by using an intact cell assay system. T3 at its physiological concentrations has no significant effect on smooth muscle cell proliferation, but it does significantly stimulate prostacyclin production by th...

journal_title：Atherosclerosis

authors： Nakao J,Chang WC,Murota S,Orimo H

更新日期：1981-07-01 00:00:00

abstract：:Pressure recordings in 120 patients, aged 0-35 years, undergoing operation for coarctation of the aorta, show a slow but steady rise in both systolic and diastolic peak pressures, the highest peak registered being in patients aged 16-18 years. The finding of significant morphological changes in the aorta in this age g...

journal_title：Atherosclerosis

authors： Anyanwu E,Dittrich H,Jelesijević V,Drüen B,Krefting ER,Höhling H

更新日期：1981-06-01 00:00:00